Main features Qualitative detection of aberrant expression of the tyrosin-kinase domain of ALK associated to the gene fusion by retrotrascription and co-amplification of a region located at 3’ terminus of ALK mRNA (detected by a FAM marked probe) and of an endogenous control gene (detected by a HEX marked probe). Controls Control RNA for the monitoring of the analytical process. Sensitivity The kit allows the detection of low percentages of mutated allele in presence of high amounts of wild-type genomic DNA by real-time amplification with sequence-specific probes marked with FAM and HEX (LOD down to 0.5%). Starting material The kit allows the analysis of DNA extracted from fresh, frozen and formalin-fixed paraffin-embedded tissue.
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