REALQUALITY RQ-BCR-ABL p190 One-Step

REALQUALITY RQ-BCR-ABL p190 One-Step Detection of the t(9;22) p190 Translocation Using One-Step Real-Time RT-PCR

The REALQUALITY RQ-BCR-ABL p190 is a highly accurate and reliable molecular diagnostic kit developed by the Italian company AB Analitica.
It is specifically designed for the detection and quantification of p190 transcripts using a One-Step Real-Time RT-PCR method.
This kit is particularly useful in the diagnosis of Acute Lymphoblastic Leukemia (ALL) and for monitoring Minimal Residual Disease (MRD).

Key FeaturesREALQUALITY RQ-BCR-ABL p190 One-Step :

Developed in accordance with international standards and “Europe Against Cancer” protocols
Requires only 5 µL of extracted RNA
Includes an internal fluorescent normalizer and a dUTP/UNG system to prevent contamination
Shares a thermal profile with the RQ-BCR-ABL p210 kit, allowing parallel testing
Compatible with major Real-Time PCR platforms

🇮🇷 Exclusive Distributor in Iran:

Fardad Azma Rad Co. is the exclusive representative of AB Analitica in Iran,
offering this product with full authenticity guarantee, expert consultation, and technical support.

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Additional Information:

The Philadelphia chromosome (Ph) was the first cytogenetic abnormality identified in cancer. It results from the t(9;22)(q34;q11) translocation and appears in over 95% of Chronic Myeloid Leukemia (CML) cases. It’s also present in 5% of childhood Acute Lymphoblastic Leukemia (ALL) cases and 10-25% of adult ALL cases. At the molecular level, this translocation involves the ABL gene on chromosome 9 being transferred to a region within the BCR gene on chromosome 22. The breakpoints may vary, leading to different fusion proteins. Most CML cases and many Philadelphia-positive ALL cases involve breakpoints in specific regions of the BCR gene, resulting in unique fusion proteins that cause unchecked cell proliferation. Detecting this translocation helps clinicians diagnose the leukemia type, predict disease progression, and monitor disease residuals for effective treatment management.