MUM1 Antibody (Immunohistochemistry)

MUM1 Antibody (Immunohistochemistry)

The MUM1 (Multiple Myeloma Oncogene 1) Antibody is a highly specific immunohistochemical marker used in the diagnosis of B-cell, plasma cell, and certain T-cell neoplasms.
MUM1 is a 50 kDa nuclear protein encoded by the MUM1/IRF4 gene located on chromosome 6q23–25, functioning as a myeloma-associated oncogene.

MUM1 protein is expressed in plasma cells and activated lymphocytes. Detection of MUM1 expression through immunohistochemistry provides pathologists with valuable diagnostic information, especially for multiple myeloma, diffuse large B-cell lymphoma (DLBCL), and plasmacytoma.

🔬 Features and Benefits

• Specific marker for plasma and activated B-cells: Enables precise diagnosis in hematologic neoplasms

• Distinct nuclear staining: Brown color visible in nuclei of positive cells

• Broad diagnostic utility: Effective for identifying multiple myeloma, DLBCL, and plasmacytoma

• Compatible with standard IHC protocols: Suitable for both clinical and research laboratories

• Excellent stability: Reliable performance for 18 months at 2–8 °C

⚙️ Principle of the Assay

During the IHC process, the MUM1 antibody binds to the nuclear antigen in B and plasma cells. The HRP-conjugated secondary antibody then binds to the primary antibody, forming the antigen–antibody–HRP complex.
Upon addition of the DAB chromogen, a brown insoluble staining appears in the nuclei of positive cells, indicating MUM1 expression.

💡 Diagnostic Applications

• Detection of Multiple Myeloma, Diffuse Large B-Cell Lymphoma (DLBCL), and Plasmacytoma

• Differentiation between B-cell and T-cell neoplasms

• Research studies in immunopathology and lymphoid cell activation

🌐 Fardad Azma Rad Co.

Fardad Azma Rad Co., the exclusive representative of Talent Biomedical in Iran, is the official supplier of high-quality immunohistochemistry antibodies, including MUM1.
With a focus on accuracy, reliability, and compliance with global standards, Fardad Azma Rad provides advanced diagnostic and molecular pathology solutions for hospitals, laboratories, and research institutions across Iran.

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