D2-40 Antibody (Immunohistochemistry)

 D2-40 Antibody (Immunohistochemistry)

The D2-40 Antibody is a highly specific immunohistochemical marker used to identify tumors with lymphoendothelial differentiation. It is a well-established marker for Kaposi sarcoma, as well as other vascular neoplasms such as hepatic epithelioid hemangioendothelioma and central nervous system (CNS) hemangioblastoma.

The D2-40 antibody helps pathologists distinguish between lymphatic endothelial-derived tumors and other non-vascular neoplasms, making it an essential tool in diagnostic pathology.

🔬 Features and Benefits

• Specific marker for lymphatic endothelium: Accurately identifies lymphatic and vascular differentiation in tumors

• Clear and distinct staining: Brown staining visible in both cytoplasm and cell membranes

• Broad diagnostic utility: Effective in detecting Kaposi sarcoma and vascular lesions

• Compatible with standard IHC protocols: Suitable for all clinical and research pathology laboratories

• High stability and reliability: Consistent performance at 2–8 °C with 18-month shelf life

⚙️ Principle of the Assay

During the IHC process, the D2-40 antibody binds to the target antigen within the tissue section. A secondary antibody conjugated with HRP attaches to the primary antibody, forming the antigen–antibody–HRP complex. When the DAB chromogen is added, a brown insoluble staining appears in the cytoplasm and membrane of positive cells, confirming the antigen expression.

💡 Diagnostic Applications

• Diagnosis of Kaposi sarcoma

• Identification of hepatic epithelioid hemangioendothelioma

• Detection of CNS hemangioblastoma

• Differentiation of vascular and non-vascular tumors

• Research in lymphatic endothelial cell markers

🌐 Fardad Azma Rad Co.

Fardad Azma Rad Co., the exclusive representative of Talent Biomedical in Iran, supplies advanced immunohistochemistry antibodies, including D2-40.
Committed to precision, quality, and international standards, the company provides high-performance diagnostic products and molecular pathology solutions to laboratories and research institutions across Iran.

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