{"id":1769,"date":"2025-06-03T10:16:18","date_gmt":"2025-06-03T06:46:18","guid":{"rendered":"https:\/\/fardadazma.com\/en\/?post_type=product&#038;p=1769"},"modified":"2025-11-19T14:27:00","modified_gmt":"2025-11-19T10:57:00","slug":"pms2-rabbit-monoclonal-antibody-6ml","status":"publish","type":"product","link":"https:\/\/fardadazma.com\/en\/product\/pms2-rabbit-monoclonal-antibody-6ml\/","title":{"rendered":"PMS2 Antibody (Immunohistochemistry)"},"content":{"rendered":"<h2 data-start=\"1793\" data-end=\"1841\"><strong data-start=\"1801\" data-end=\"1841\">PMS2 Antibody (Immunohistochemistry)<\/strong><\/h2>\n<p data-start=\"1843\" data-end=\"2100\">The <strong data-start=\"1847\" data-end=\"1902\"><a href=\"https:\/\/fardadazma.com\/en\/product-category\/pathology\/\">PMS2 (Postmeiotic Segregation Increased 2)<\/a> Antibody<\/strong> is one of the four key markers used to evaluate the <strong data-start=\"1955\" data-end=\"1980\">Mismatch Repair (MMR)<\/strong> system for detecting <strong data-start=\"2002\" data-end=\"2038\">Microsatellite Instability (MSI)<\/strong>, particularly in <strong data-start=\"2056\" data-end=\"2097\">colorectal and endometrial carcinomas<\/strong>.<\/p>\n<p data-start=\"2102\" data-end=\"2386\">PMS2 protein, along with MLH1, MSH2, and MSH6, plays an essential role in correcting DNA replication errors.<br data-start=\"2210\" data-end=\"2213\" \/>Loss of PMS2 nuclear staining by IHC is a major indicator of <strong data-start=\"2274\" data-end=\"2297\">defective MMR genes<\/strong>, often associated with <strong data-start=\"2321\" data-end=\"2383\">Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer)<\/strong>.<\/p>\n<hr data-start=\"2388\" data-end=\"2391\" \/>\n<h3 data-start=\"2393\" data-end=\"2423\">\ud83d\udd2c Features and Benefits<\/h3>\n<ul data-start=\"2424\" data-end=\"2752\">\n<li data-start=\"2424\" data-end=\"2470\">\n<p data-start=\"2426\" data-end=\"2470\"><strong data-start=\"2426\" data-end=\"2468\">Core marker for MMR pathway assessment<\/strong><\/p>\n<\/li>\n<li data-start=\"2471\" data-end=\"2558\">\n<p data-start=\"2473\" data-end=\"2558\"><strong data-start=\"2473\" data-end=\"2503\">Distinct nuclear staining:<\/strong> Brown in normal cells; loss indicates MMR deficiency<\/p>\n<\/li>\n<li data-start=\"2559\" data-end=\"2646\">\n<p data-start=\"2561\" data-end=\"2646\"><strong data-start=\"2561\" data-end=\"2584\">Clinical relevance:<\/strong> Essential in identifying Lynch syndrome and MSI-high tumors<\/p>\n<\/li>\n<li data-start=\"2647\" data-end=\"2693\">\n<p data-start=\"2649\" data-end=\"2693\"><strong data-start=\"2649\" data-end=\"2691\">Compatible with standard IHC protocols<\/strong><\/p>\n<\/li>\n<li data-start=\"2694\" data-end=\"2752\">\n<p data-start=\"2696\" data-end=\"2752\"><strong data-start=\"2696\" data-end=\"2720\">Excellent stability:<\/strong> 18-month shelf life at 2\u20138 \u00b0C<\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"2754\" data-end=\"2757\" \/>\n<h3 data-start=\"2759\" data-end=\"2791\">\ud83d\udca1 Diagnostic Applications<\/h3>\n<ul data-start=\"2792\" data-end=\"3007\">\n<li data-start=\"2792\" data-end=\"2847\">\n<p data-start=\"2794\" data-end=\"2847\">Evaluation of <strong data-start=\"2808\" data-end=\"2845\">Mismatch Repair deficiency (dMMR)<\/strong><\/p>\n<\/li>\n<li data-start=\"2848\" data-end=\"2883\">\n<p data-start=\"2850\" data-end=\"2883\">Diagnosis of <strong data-start=\"2863\" data-end=\"2881\">Lynch Syndrome<\/strong><\/p>\n<\/li>\n<li data-start=\"2884\" data-end=\"2949\">\n<p data-start=\"2886\" data-end=\"2949\">Assessment of <strong data-start=\"2900\" data-end=\"2947\">MSI-high colorectal and endometrial cancers<\/strong><\/p>\n<\/li>\n<li data-start=\"2950\" data-end=\"3007\">\n<p data-start=\"2952\" data-end=\"3007\">Research studies on <strong data-start=\"2972\" data-end=\"3005\">genomic instability in tumors<\/strong><\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"3009\" data-end=\"3012\" \/>\n<h3 data-start=\"3014\" data-end=\"3042\">\ud83c\udf10 Fardad Azma Rad Co.<\/h3>\n<p data-start=\"3044\" data-end=\"3392\"><strong data-start=\"3044\" data-end=\"3067\"><a href=\"https:\/\/fardadazma.com\/en\/about\/\">Fardad Azma Rad<\/a> Co.<\/strong>, the <strong data-start=\"3073\" data-end=\"3122\">exclusive representative of <a href=\"https:\/\/fardadazma.com\/en\/talent\/\">Talent Biomedical<\/a><\/strong> in Iran, distributes high-quality <strong data-start=\"3157\" data-end=\"3192\">immunohistochemistry antibodies<\/strong>, including <strong data-start=\"3204\" data-end=\"3212\">PMS2<\/strong>.<br data-start=\"3213\" data-end=\"3216\" \/>With commitment to <strong data-start=\"3235\" data-end=\"3293\">accuracy, reliability, and global diagnostic standards<\/strong>, the company provides advanced histopathological and molecular diagnostic solutions across Iran.<\/p>\n<p><a href=\"https:\/\/fardadazma.com\/wp-content\/uploads\/2025\/10\/PMS2-Instruction-for-Use.pdf\"><strong>&#8220;Download Brochure&#8221;<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<table>\n<thead>\n<tr>\n<th>Specification<\/th>\n<th>Description \/ Value<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Product Name<\/td>\n<td>PMS2\u00a0 Antibody<\/td>\n<\/tr>\n<tr>\n<td>Clone<\/td>\n<td>Not specified (manufacturer dependent)<\/td>\n<\/tr>\n<tr>\n<td>Antibody Type<\/td>\n<td>Rabbit Monoclonal<\/td>\n<\/tr>\n<tr>\n<td>Main Application<\/td>\n<td>Immunohistochemistry (IHC)<\/td>\n<\/tr>\n<tr>\n<td>Target<\/td>\n<td>Detection of PMS2 protein in human tissues<\/td>\n<\/tr>\n<tr>\n<td>Target Organs<\/td>\n<td>Colorectal, Endometrium<\/td>\n<\/tr>\n<tr>\n<td>Isotype<\/td>\n<td>IgG<\/td>\n<\/tr>\n<tr>\n<td>Volume<\/td>\n<td>6 ml<\/td>\n<\/tr>\n<tr>\n<td>Storage Temperature<\/td>\n<td>2\u20138\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>Recommended Positive Control<\/td>\n<td>Colorectal tumor tissue with normal PMS2 expression<\/td>\n<\/tr>\n<tr>\n<td>Format<\/td>\n<td>Ready-to-use or Concentrated (depending on brand)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":2657,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[27],"product_tag":[1250,1093,883,1265,1176,1197,1036],"class_list":{"0":"post-1769","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-pathology","7":"product_tag-6ml-volume","8":"product_tag-colorectal-cancer-marker","9":"product_tag-diagnostic-reagent","10":"product_tag-dna-mismatch-repair-protein","11":"product_tag-immunohistochemistry","12":"product_tag-pathology-research","13":"product_tag-rabbit-monoclonal-antibody","15":"first","16":"instock","17":"shipping-taxable","18":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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