{"id":1450,"date":"2025-05-20T14:52:45","date_gmt":"2025-05-20T11:22:45","guid":{"rendered":"https:\/\/fardadazma.com\/en\/?post_type=product&#038;p=1450"},"modified":"2025-11-30T16:19:10","modified_gmt":"2025-11-30T12:49:10","slug":"realquality-rq-pml-rara-bcr3-one-step","status":"publish","type":"product","link":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/","title":{"rendered":"REALQUALITY RQ-PML-RARa bcr3 One-Step"},"content":{"rendered":"<h1><strong>REALQUALITY RQ-PML-RAR\u03b1 bcr3 One-Step<\/strong><\/h1>\n<p><strong>REALQUALITY RQ-PML-RAR\u03b1 bcr3 One-Step<\/strong> is a molecular diagnostic kit designed for the<br \/>\ndetection of the <strong>PML-RAR\u03b1 bcr3 transcript<\/strong> associated with<br \/>\n<strong>Acute Promyelocytic Leukemia (APL)<\/strong> and the <strong>t(15;17) translocation<\/strong>.<br \/>\nIt uses a <strong>One-Step Real-Time RT-PCR<\/strong> format that allows fast, sensitive, and streamlined analysis.<br \/>\nThis method reduces hands-on time and improves workflow efficiency in molecular laboratories.<\/p>\n<p>The detection of bcr3 transcripts is essential for APL diagnosis and follow-up because it supports rapid<br \/>\nclinical decision-making. Furthermore, early identification of transcript levels helps clinicians monitor<br \/>\ntreatment response and track Minimal Residual Disease (MRD). The One-Step design simplifies RNA handling,<br \/>\nreduces contamination risk, and ensures consistent performance across multiple assays.<\/p>\n<h2><strong>Key Features of REALQUALITY RQ-PML-RAR\u03b1 bcr3 One-Step<\/strong><\/h2>\n<ul>\n<li>Developed according to <strong>international guidelines<\/strong> for APL molecular monitoring<\/li>\n<li>Specific detection of the <strong>bcr3 transcript<\/strong> from the PML-RAR\u03b1 fusion<\/li>\n<li>Includes an <strong>internal fluorescent normalizer<\/strong> for enhanced quality control<\/li>\n<li>Features a <strong>dUTP\/UNG system<\/strong> to prevent PCR carryover contamination<\/li>\n<li>Requires only <strong>5 \u00b5L of extracted RNA<\/strong> for analysis<\/li>\n<li>Shares a unified thermal profile with other PML-RAR\u03b1 assays for easier parallel runs<\/li>\n<li>Suitable for <strong>treatment response monitoring<\/strong> and <strong>MRD detection<\/strong> in APL patients<\/li>\n<\/ul>\n<h2><strong>Compatible With<\/strong><\/h2>\n<ul>\n<li><strong>REALQUALITY RQ-PML-RAR\u03b1 bcr3 STANDARD<\/strong><br \/>\nProvides <strong>quantitative calibration<\/strong> and supports <strong>standard curve generation<\/strong><br \/>\nfor accurate MRD tracking.<\/li>\n<\/ul>\n<h2>\ud83c\uddee\ud83c\uddf7 <strong>Exclusive Distribution in Iran<\/strong><\/h2>\n<p><strong><a href=\"https:\/\/fardadazma.com\/about\/\">Fardad Azma Rad Co.<\/a><\/strong> is the exclusive representative<br \/>\nof <strong>AB Analitica<\/strong> in Iran. The company supplies the One-Step kit to diagnostic and research centers<br \/>\nacross the country. It ensures:<\/p>\n<ul>\n<li><strong>Guaranteed authenticity<\/strong> of all imported kits<\/li>\n<li><strong>Specialized training<\/strong> for laboratory personnel<\/li>\n<li><strong>Scientific and technical support<\/strong> by experienced specialists<\/li>\n<li><strong>Fast and reliable distribution<\/strong> across Iran<\/li>\n<\/ul>\n<p>This One-Step assay is an essential tool for laboratories seeking accurate and standardized detection of<br \/>\nPML-RAR\u03b1 bcr3 transcripts. It improves workflow simplicity, enhances diagnostic reliability, and supports<br \/>\nbetter clinical outcomes in APL management.<\/p>\n<p><a style=\"font-size: 16px\" href=\"\/wp-content\/uploads\/2025\/02\/20240322-ONCHOEMATOLOGY_brochure-9_11zon.pdf\"><strong>Download Catalog<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><strong data-start=\"817\" data-end=\"844\">Additional Information:<\/strong><br data-start=\"844\" data-end=\"847\" \/>The t(15;17)(q22;q21) translocation is commonly associated with Acute Promyelocytic Leukemia (APL), a subtype of Acute Myeloid Leukemia (AML) with M3 morphology. APL accounts for approximately 10-15% of AML cases. This translocation results from the fusion of the PML gene (located on chromosome 15q22) and the RARa gene (located on chromosome 17q21). The breakpoint in the RARa gene is located within a 15 kb region of intron 2, while the breakpoint in the PML gene can occur in three different regions: intron 6 (55% of cases), intron 3 (40% of cases), and exon 6 (5% of cases). Each breakpoint is associated with a specific PML-RARa isoform named bcr1, bcr3, and bcr2, respectively. The fusion protein acts as a transcriptional repressor, blocking differentiation of hematopoietic stem cells and arresting them at the promyelocytic stage. Treatment with ATRA (All-Trans Retinoic Acid) is highly effective in APL, acting as an inducer of differentiation.<\/p>\n<p class=\"\" data-start=\"2465\" data-end=\"2532\">\n","protected":false},"featured_media":1451,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[28],"product_tag":[372,371,378,393,377,374,391,388,390,392,389],"class_list":{"0":"post-1450","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-genetics","7":"product_tag-acute-myeloid-leukemia-aml","8":"product_tag-acute-promyelocytic-leukemia-apl","9":"product_tag-atra-treatment","10":"product_tag-dutp-ung-assay","11":"product_tag-extracted-rna","12":"product_tag-pml-gene","13":"product_tag-pml-rara-bcr3-transcripts","14":"product_tag-rara-gene","15":"product_tag-realquality-rq-bcr-abl-kits","16":"product_tag-realquality-rq-pml-rara-bcr3-kit","17":"product_tag-t1517q22q21-translocation","19":"first","20":"instock","21":"shipping-taxable","22":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>REALQUALITY RQ-PML-RARa bcr3 One-Step - Fardadazma<\/title>\n<meta name=\"description\" content=\"REALQUALITY RQ-PML-RAR\u03b1 bcr3 One-Step is a highly accurate molecular diagnostic kit developed by AB Analitica (Italy),\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"REALQUALITY RQ-PML-RARa bcr3 One-Step - Fardadazma\" \/>\n<meta property=\"og:description\" content=\"REALQUALITY RQ-PML-RAR\u03b1 bcr3 One-Step is a highly accurate molecular diagnostic kit developed by AB Analitica (Italy),\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/\" \/>\n<meta property=\"og:site_name\" content=\"Fardadazma\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-30T12:49:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr2-standard-abanalitica-400x311-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"311\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/\",\"url\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/\",\"name\":\"REALQUALITY RQ-PML-RARa bcr3 One-Step - Fardadazma\",\"isPartOf\":{\"@id\":\"https:\/\/fardadazma.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr2-standard-abanalitica-400x311-1.jpg\",\"datePublished\":\"2025-05-20T11:22:45+00:00\",\"dateModified\":\"2025-11-30T12:49:10+00:00\",\"description\":\"REALQUALITY RQ-PML-RAR\u03b1 bcr3 One-Step is a highly accurate molecular diagnostic kit developed by AB Analitica (Italy),\",\"breadcrumb\":{\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/#primaryimage\",\"url\":\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr2-standard-abanalitica-400x311-1.jpg\",\"contentUrl\":\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr2-standard-abanalitica-400x311-1.jpg\",\"width\":400,\"height\":311,\"caption\":\"REALQUALITY RQ-PML-RARa bcr3 STANDARD\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u062e\u0627\u0646\u0647\",\"item\":\"https:\/\/fardadazma.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\/\/fardadazma.com\/en\/shop\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"REALQUALITY RQ-PML-RARa bcr3 One-Step\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fardadazma.com\/en\/#website\",\"url\":\"https:\/\/fardadazma.com\/en\/\",\"name\":\"Fardadazma\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/fardadazma.com\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fardadazma.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fardadazma.com\/en\/#organization\",\"name\":\"Fardadazma\",\"url\":\"https:\/\/fardadazma.com\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fardadazma.com\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2024\/10\/logo.png\",\"contentUrl\":\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2024\/10\/logo.png\",\"width\":300,\"height\":69,\"caption\":\"Fardadazma\"},\"image\":{\"@id\":\"https:\/\/fardadazma.com\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"REALQUALITY RQ-PML-RARa bcr3 One-Step - Fardadazma","description":"REALQUALITY RQ-PML-RAR\u03b1 bcr3 One-Step is a highly accurate molecular diagnostic kit developed by AB Analitica (Italy),","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/","og_locale":"en_US","og_type":"article","og_title":"REALQUALITY RQ-PML-RARa bcr3 One-Step - Fardadazma","og_description":"REALQUALITY RQ-PML-RAR\u03b1 bcr3 One-Step is a highly accurate molecular diagnostic kit developed by AB Analitica (Italy),","og_url":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/","og_site_name":"Fardadazma","article_modified_time":"2025-11-30T12:49:10+00:00","og_image":[{"width":400,"height":311,"url":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr2-standard-abanalitica-400x311-1.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/","url":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/","name":"REALQUALITY RQ-PML-RARa bcr3 One-Step - Fardadazma","isPartOf":{"@id":"https:\/\/fardadazma.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/#primaryimage"},"image":{"@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/#primaryimage"},"thumbnailUrl":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr2-standard-abanalitica-400x311-1.jpg","datePublished":"2025-05-20T11:22:45+00:00","dateModified":"2025-11-30T12:49:10+00:00","description":"REALQUALITY RQ-PML-RAR\u03b1 bcr3 One-Step is a highly accurate molecular diagnostic kit developed by AB Analitica (Italy),","breadcrumb":{"@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/#primaryimage","url":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr2-standard-abanalitica-400x311-1.jpg","contentUrl":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr2-standard-abanalitica-400x311-1.jpg","width":400,"height":311,"caption":"REALQUALITY RQ-PML-RARa bcr3 STANDARD"},{"@type":"BreadcrumbList","@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr3-one-step\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u062e\u0627\u0646\u0647","item":"https:\/\/fardadazma.com\/en\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/fardadazma.com\/en\/shop\/"},{"@type":"ListItem","position":3,"name":"REALQUALITY RQ-PML-RARa bcr3 One-Step"}]},{"@type":"WebSite","@id":"https:\/\/fardadazma.com\/en\/#website","url":"https:\/\/fardadazma.com\/en\/","name":"Fardadazma","description":"","publisher":{"@id":"https:\/\/fardadazma.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fardadazma.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fardadazma.com\/en\/#organization","name":"Fardadazma","url":"https:\/\/fardadazma.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fardadazma.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2024\/10\/logo.png","contentUrl":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2024\/10\/logo.png","width":300,"height":69,"caption":"Fardadazma"},"image":{"@id":"https:\/\/fardadazma.com\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product\/1450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/comments?post=1450"}],"version-history":[{"count":4,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product\/1450\/revisions"}],"predecessor-version":[{"id":3427,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product\/1450\/revisions\/3427"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/media\/1451"}],"wp:attachment":[{"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/media?parent=1450"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product_brand?post=1450"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product_cat?post=1450"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product_tag?post=1450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}