{"id":1444,"date":"2025-05-20T14:19:48","date_gmt":"2025-05-20T10:49:48","guid":{"rendered":"https:\/\/fardadazma.com\/en\/?post_type=product&#038;p=1444"},"modified":"2025-11-30T16:19:17","modified_gmt":"2025-11-30T12:49:17","slug":"realquality-rq-pml-rara-bcr1-one-step","status":"publish","type":"product","link":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/","title":{"rendered":"REALQUALITY RQ-PML-RARa bcr1 One-Step"},"content":{"rendered":"<h1><strong>REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step<\/strong><\/h1>\n<p><strong>REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step<\/strong> is a molecular diagnostic kit developed by AB Analitica (Italy).<br \/>\nIt is designed for the <strong>detection and quantification of the PML-RAR\u03b1 bcr1 transcript<\/strong>, which is associated with<br \/>\n<strong>Acute Promyelocytic Leukemia (APL)<\/strong> and the <strong>t(15;17) translocation<\/strong>.<br \/>\nThis kit uses a One-Step Real-Time RT-PCR format that enables fast, efficient, and highly accurate molecular testing.<\/p>\n<p>The detection of the bcr1 isoform is essential in APL diagnostics because it provides clinicians with reliable molecular<br \/>\nmarkers for early diagnosis and treatment monitoring. The One-Step workflow reduces manual steps, prevents contamination,<br \/>\nand ensures consistent amplification. As a result, laboratories benefit from reproducible results and a simplified<br \/>\ndiagnostic process.<\/p>\n<h2><strong>Technical Features of REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step<\/strong><\/h2>\n<ul>\n<li>Specific detection of the <strong>t(15;17)(q24;q21)<\/strong> translocation, bcr1 variant<\/li>\n<li>Developed in line with <strong>international guidelines<\/strong> for APL molecular testing<\/li>\n<li>Includes a <strong>dUTP\/UNG system<\/strong> to prevent PCR carryover contamination<\/li>\n<li>Contains an <strong>internal fluorescent normalizer<\/strong> for assay quality control<\/li>\n<li>Requires only <strong>5 \u03bcL of extracted RNA<\/strong> for each reaction<\/li>\n<li>Ideal for <strong>treatment response monitoring<\/strong> and MRD detection<\/li>\n<li>Compatible with all major <strong>Real-Time PCR platforms<\/strong><\/li>\n<\/ul>\n<h2><strong>Clinical Applications of REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step<\/strong><\/h2>\n<ul>\n<li>Detection of PML-RAR\u03b1 bcr1 transcripts in APL patients<\/li>\n<li>Monitoring Minimal Residual Disease (MRD) levels<\/li>\n<li>Evaluating treatment response throughout therapy<\/li>\n<li>Supporting consistent molecular follow-up in hematology laboratories<\/li>\n<\/ul>\n<h2>\ud83c\uddee\ud83c\uddf9 <strong>About AB Analitica<\/strong><\/h2>\n<p><strong>AB Analitica<\/strong> is a leading Italian manufacturer of advanced <strong>molecular diagnostic kits<\/strong>.<br \/>\nAll products are developed in full compliance with <strong>European clinical and quality standards<\/strong>, ensuring<br \/>\nhigh analytical performance and long-term reliability in diagnostic workflows.<\/p>\n<h2>\ud83c\uddee\ud83c\uddf7 <strong>Exclusive Distributor in Iran<\/strong><\/h2>\n<p><strong><a href=\"https:\/\/fardadazma.com\/about\/\">Fardad Azma Rad Co.<\/a><\/strong> is the exclusive representative of AB Analitica<br \/>\nin Iran. The company provides REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step to molecular diagnostic laboratories nationwide.<br \/>\nServices include:<\/p>\n<ul>\n<li><strong>Certified authenticity<\/strong> for all imported kits<\/li>\n<li><strong>Expert training<\/strong> for laboratory per<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p data-start=\"800\" data-end=\"1531\"><strong data-start=\"800\" data-end=\"827\">Additional Information:<\/strong><br data-start=\"827\" data-end=\"830\" \/>The t(15;17)(q22;q21) translocation is commonly associated with Acute Promyelocytic Leukemia (APL), a subtype of Acute Myeloid Leukemia (AML) classified as M3 morphology. APL accounts for approximately 10-15% of AML cases. This translocation results from the fusion of the PML gene on chromosome 15 and the RARa (Retinoic Acid Receptor alpha) gene on chromosome 17. Breakpoints in these genes occur in different regions, producing specific PML-RARa isoforms named bcr1, bcr2, and bcr3. The fusion protein blocks differentiation of hematopoietic stem cells, arresting them at the promyelocyte stage. Treatment with ATRA (All-Trans Retinoic Acid) is highly effective in APL by promoting differentiation.<\/p>\n","protected":false},"featured_media":1445,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[28],"product_tag":[372,371,378,377,376,374,379,351,375,373],"class_list":{"0":"post-1444","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-genetics","7":"product_tag-acute-myeloid-leukemia-aml","8":"product_tag-acute-promyelocytic-leukemia-apl","9":"product_tag-atra-treatment","10":"product_tag-extracted-rna","11":"product_tag-gene-transcript-quantification","12":"product_tag-pml-gene","13":"product_tag-pml-rara-fusion-protein","14":"product_tag-real-time-pcr-kit","15":"product_tag-retinoic-acid-receptor-alpha-rara","16":"product_tag-t1517-chromosomal-translocation","18":"first","19":"instock","20":"shipping-taxable","21":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>REALQUALITY RQ-PML-RARa bcr1 One-Step - Fardadazma<\/title>\n<meta name=\"description\" content=\"REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step is a molecular diagnostic kit developed byAB Analitica (Italy).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"REALQUALITY RQ-PML-RARa bcr1 One-Step - Fardadazma\" \/>\n<meta property=\"og:description\" content=\"REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step is a molecular diagnostic kit developed byAB Analitica (Italy).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/\" \/>\n<meta property=\"og:site_name\" content=\"Fardadazma\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-30T12:49:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr1-kit-abanalitica-Copia-400x311-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"311\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/\",\"url\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/\",\"name\":\"REALQUALITY RQ-PML-RARa bcr1 One-Step - Fardadazma\",\"isPartOf\":{\"@id\":\"https:\/\/fardadazma.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr1-kit-abanalitica-Copia-400x311-1.jpg\",\"datePublished\":\"2025-05-20T10:49:48+00:00\",\"dateModified\":\"2025-11-30T12:49:17+00:00\",\"description\":\"REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step is a molecular diagnostic kit developed byAB Analitica (Italy).\",\"breadcrumb\":{\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/#primaryimage\",\"url\":\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr1-kit-abanalitica-Copia-400x311-1.jpg\",\"contentUrl\":\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr1-kit-abanalitica-Copia-400x311-1.jpg\",\"width\":400,\"height\":311},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u062e\u0627\u0646\u0647\",\"item\":\"https:\/\/fardadazma.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\/\/fardadazma.com\/en\/shop\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"REALQUALITY RQ-PML-RARa bcr1 One-Step\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fardadazma.com\/en\/#website\",\"url\":\"https:\/\/fardadazma.com\/en\/\",\"name\":\"Fardadazma\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/fardadazma.com\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fardadazma.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fardadazma.com\/en\/#organization\",\"name\":\"Fardadazma\",\"url\":\"https:\/\/fardadazma.com\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fardadazma.com\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2024\/10\/logo.png\",\"contentUrl\":\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2024\/10\/logo.png\",\"width\":300,\"height\":69,\"caption\":\"Fardadazma\"},\"image\":{\"@id\":\"https:\/\/fardadazma.com\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"REALQUALITY RQ-PML-RARa bcr1 One-Step - Fardadazma","description":"REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step is a molecular diagnostic kit developed byAB Analitica (Italy).","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/","og_locale":"en_US","og_type":"article","og_title":"REALQUALITY RQ-PML-RARa bcr1 One-Step - Fardadazma","og_description":"REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step is a molecular diagnostic kit developed byAB Analitica (Italy).","og_url":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/","og_site_name":"Fardadazma","article_modified_time":"2025-11-30T12:49:17+00:00","og_image":[{"width":400,"height":311,"url":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr1-kit-abanalitica-Copia-400x311-1.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/","url":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/","name":"REALQUALITY RQ-PML-RARa bcr1 One-Step - Fardadazma","isPartOf":{"@id":"https:\/\/fardadazma.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/#primaryimage"},"image":{"@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/#primaryimage"},"thumbnailUrl":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr1-kit-abanalitica-Copia-400x311-1.jpg","datePublished":"2025-05-20T10:49:48+00:00","dateModified":"2025-11-30T12:49:17+00:00","description":"REALQUALITY RQ-PML-RAR\u03b1 bcr1 One-Step is a molecular diagnostic kit developed byAB Analitica (Italy).","breadcrumb":{"@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/#primaryimage","url":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr1-kit-abanalitica-Copia-400x311-1.jpg","contentUrl":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-PML-RARa-bcr1-kit-abanalitica-Copia-400x311-1.jpg","width":400,"height":311},{"@type":"BreadcrumbList","@id":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-pml-rara-bcr1-one-step\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u062e\u0627\u0646\u0647","item":"https:\/\/fardadazma.com\/en\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/fardadazma.com\/en\/shop\/"},{"@type":"ListItem","position":3,"name":"REALQUALITY RQ-PML-RARa bcr1 One-Step"}]},{"@type":"WebSite","@id":"https:\/\/fardadazma.com\/en\/#website","url":"https:\/\/fardadazma.com\/en\/","name":"Fardadazma","description":"","publisher":{"@id":"https:\/\/fardadazma.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fardadazma.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fardadazma.com\/en\/#organization","name":"Fardadazma","url":"https:\/\/fardadazma.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fardadazma.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2024\/10\/logo.png","contentUrl":"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2024\/10\/logo.png","width":300,"height":69,"caption":"Fardadazma"},"image":{"@id":"https:\/\/fardadazma.com\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product\/1444","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/comments?post=1444"}],"version-history":[{"count":4,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product\/1444\/revisions"}],"predecessor-version":[{"id":3429,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product\/1444\/revisions\/3429"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/media\/1445"}],"wp:attachment":[{"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/media?parent=1444"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product_brand?post=1444"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product_cat?post=1444"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/fardadazma.com\/en\/wp-json\/wp\/v2\/product_tag?post=1444"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}