{"id":1416,"date":"2025-05-19T11:23:59","date_gmt":"2025-05-19T07:53:59","guid":{"rendered":"https:\/\/fardadazma.com\/en\/?post_type=product&#038;p=1416"},"modified":"2025-11-30T16:45:12","modified_gmt":"2025-11-30T13:15:12","slug":"realquality-rq-bcr-abl-p210-one-step","status":"publish","type":"product","link":"https:\/\/fardadazma.com\/en\/product\/realquality-rq-bcr-abl-p210-one-step\/","title":{"rendered":"REALQUALITY RQ-BCR-ABL p210 One-Step"},"content":{"rendered":"<h2><strong>REALQUALITY RQ-BCR-ABL p210 One-Step Kit<\/strong><\/h2>\n<p>The REALQUALITY RQ-BCR-ABL p210 One-Step kit is designed for the detection and quantification<br \/>\nof the <strong>t(9;22)(q34;q11)<\/strong> translocation, specifically the <strong>p210 transcript<\/strong>.<br \/>\nUsing a one-step Real-Time RT-PCR method, the kit provides fast and accurate results for<br \/>\nmonitoring <strong>Chronic Myeloid Leukemia (CML)<\/strong>.<\/p>\n<h2><strong>Key Features<\/strong><\/h2>\n<ul>\n<li>Developed according to the <strong>Europe Against Cancer<\/strong> guidelines.<\/li>\n<li>Includes a <strong>dUTP\/UNG<\/strong> system to prevent PCR contamination.<\/li>\n<li>Contains an <strong>internal fluorescent normalizer<\/strong> for reliable data output.<\/li>\n<li>Requires only <strong>5 \u03bcL<\/strong> of extracted RNA for each reaction.<\/li>\n<li>When used with the <strong>RQ-BCR-ABL p210 Standard Kit<\/strong>, it allows precise MRD monitoring.<\/li>\n<li>Shares a compatible thermal profile with other REALQUALITY leukemia kits (e.g., p190).<\/li>\n<li>Validated on major Real-Time PCR instruments used in diagnostic laboratories.<\/li>\n<\/ul>\n<h2><strong>Clinical Applications<\/strong><\/h2>\n<ul>\n<li>Detection of the BCR-ABL p210 transcript.<\/li>\n<li>Monitoring treatment response in CML patients.<\/li>\n<li>Minimal Residual Disease (MRD) evaluation.<\/li>\n<\/ul>\n<h2><strong>Kit Contents<\/strong><\/h2>\n<ul>\n<li>Ready-to-use one-step Real-Time RT-PCR reagents.<\/li>\n<li>Internal control to verify reaction performance.<\/li>\n<\/ul>\n<h2><strong>About AB Analitica<\/strong><\/h2>\n<p>AB Analitica is a leading Italian manufacturer of molecular diagnostic kits.<br \/>\nThe company is known for its high-quality standards and innovative technologies.<br \/>\nIts products are widely used in hematology and oncology laboratories worldwide.<\/p>\n<h2><strong>Exclusive Distributor in Iran<\/strong><\/h2>\n<p><strong><a href=\"https:\/\/fardadazma.com\/about\/\">Fardad Azma Rad Co.<\/a><\/strong><br \/>\nis the exclusive representative of <strong>AB Analitica<\/strong> in Iran.<br \/>\nThe company provides guaranteed authenticity, specialized technical support,<br \/>\nand expert consultation for clinical and molecular laboratories.<\/p>\n<p><a href=\"\/wp-content\/uploads\/2025\/02\/20240322-ONCHOEMATOLOGY_brochure1_860115.pdf\"><strong>Download Catalog<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<h2><strong>Additional Information:<\/strong><\/h2>\n<p>The Philadelphia chromosome (<strong>Ph chromosome<\/strong>) is the hallmark cytogenetic abnormality identified in neoplastic diseases like\u00a0<strong>Chronic Myeloid Leukemia (CML)<\/strong>\u00a0and some cases of\u00a0<strong>Acute Lymphoblastic Leukemia (ALL)<\/strong>. It results from the translocation\u00a0<strong>t(9;22)(q34;q11)<\/strong>, present in over 95% of CML cases, and 5-10% of ALL cases in children and adults.<\/p>\n<p>At the molecular level, this translocation moves the\u00a0<strong>ABL (c-ABL)<\/strong>\u00a0gene from chromosome 9 to a specific region within the\u00a0<strong>BCR<\/strong>\u00a0gene on chromosome 22. The breakpoints in\u00a0<strong>BCR<\/strong>\u00a0can vary, forming different fusion transcripts.<\/p>\n<p>Most\u00a0<strong>CML<\/strong>\u00a0and\u00a0<strong>Philadelphia-positive ALL<\/strong>\u00a0cases involve the\u00a0<strong>BCR-ABL p210<\/strong>\u00a0fusion protein, produced when the breakpoint occurs between exons 12 and 16 within the\u00a0<strong>main cluster region (M-bcr)<\/strong>\u00a0of BCR. This oncogenic fusion protein has kinase activity, leading to uncontrolled cell proliferation.<\/p>\n<p>A different breakpoint in BCR, mainly seen in ALL, produces\u00a0<strong>BCR-ABL p190<\/strong>. Detection of these fusion transcripts through RNA extraction, reverse transcription, and PCR amplification provides valuable diagnostic and prognostic information, as well as disease monitoring via\u00a0<strong>Minimal Residual Disease (MRD)<\/strong>\u00a0assessment.<\/p>\n","protected":false},"featured_media":1417,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[28],"product_tag":[275,272,279,278,274,282,281,280,285,273,284,277,283,276],"class_list":{"0":"post-1416","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-genetics","7":"product_tag-acute-lymphoblastic-leukemia-all","8":"product_tag-bcr-abl-fusion-gene","9":"product_tag-bcr-abl-p190","10":"product_tag-bcr-abl-p210","11":"product_tag-chronic-myeloid-leukemia-cml","12":"product_tag-contamination-prevention-system","13":"product_tag-leukemia-detection","14":"product_tag-molecular-diagnostics","15":"product_tag-oncology-testing","16":"product_tag-philadelphia-chromosome","17":"product_tag-quantitative-analysis","18":"product_tag-real-time-rt-pcr","19":"product_tag-rna-extraction","20":"product_tag-t922q34q11-translocation","22":"first","23":"instock","24":"shipping-taxable","25":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>REALQUALITY RQ-BCR-ABL p210 One-Step - Fardadazma<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-bcr-abl-p210-one-step\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"REALQUALITY RQ-BCR-ABL p210 One-Step - Fardadazma\" \/>\n<meta property=\"og:description\" content=\"Additional Information: The Philadelphia chromosome (Ph chromosome) is the hallmark cytogenetic abnormality identified in neoplastic diseases like\u00a0Chronic Myeloid Leukemia (CML)\u00a0and some cases of\u00a0Acute Lymphoblastic Leukemia (ALL). It results from the translocation\u00a0t(9;22)(q34;q11), present in over 95% of CML cases, and 5-10% of ALL cases in children and adults.  At the molecular level, this translocation moves the\u00a0ABL (c-ABL)\u00a0gene from chromosome 9 to a specific region within the\u00a0BCR\u00a0gene on chromosome 22. The breakpoints in\u00a0BCR\u00a0can vary, forming different fusion transcripts.  Most\u00a0CML\u00a0and\u00a0Philadelphia-positive ALL\u00a0cases involve the\u00a0BCR-ABL p210\u00a0fusion protein, produced when the breakpoint occurs between exons 12 and 16 within the\u00a0main cluster region (M-bcr)\u00a0of BCR. This oncogenic fusion protein has kinase activity, leading to uncontrolled cell proliferation.  A different breakpoint in BCR, mainly seen in ALL, produces\u00a0BCR-ABL p190. Detection of these fusion transcripts through RNA extraction, reverse transcription, and PCR amplification provides valuable diagnostic and prognostic information, as well as disease monitoring via\u00a0Minimal Residual Disease (MRD)\u00a0assessment.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-bcr-abl-p210-one-step\/\" \/>\n<meta property=\"og:site_name\" content=\"Fardadazma\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-30T13:15:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fardadazma.com\/en\/wp-content\/uploads\/sites\/2\/2025\/05\/REALQUALITY-RQ-BCR-ABL-p210-One-Step-standard-abanalitica-514x400-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"514\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-bcr-abl-p210-one-step\/\",\"url\":\"https:\/\/fardadazma.com\/en\/product\/realquality-rq-bcr-abl-p210-one-step\/\",\"name\":\"REALQUALITY RQ-BCR-ABL p210 One-Step - 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It results from the translocation\u00a0t(9;22)(q34;q11), present in over 95% of CML cases, and 5-10% of ALL cases in children and adults.  At the molecular level, this translocation moves the\u00a0ABL (c-ABL)\u00a0gene from chromosome 9 to a specific region within the\u00a0BCR\u00a0gene on chromosome 22. The breakpoints in\u00a0BCR\u00a0can vary, forming different fusion transcripts.  Most\u00a0CML\u00a0and\u00a0Philadelphia-positive ALL\u00a0cases involve the\u00a0BCR-ABL p210\u00a0fusion protein, produced when the breakpoint occurs between exons 12 and 16 within the\u00a0main cluster region (M-bcr)\u00a0of BCR. This oncogenic fusion protein has kinase activity, leading to uncontrolled cell proliferation.  A different breakpoint in BCR, mainly seen in ALL, produces\u00a0BCR-ABL p190. 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