MLH1 Antibody (Immunohistochemistry)

The MLH1 Antibody is an essential immunohistochemical marker used in evaluating the
Mismatch Repair (MMR) pathway, particularly in the diagnosis of
colorectal cancer and
genetic MMR defects.
MLH1 is a critical component of the MMR system, responsible for recognizing and repairing DNA replication errors to maintain genomic stability.

Loss of MLH1 expression is a major indicator of
MMR deficiency and is strongly associated with
Hereditary Nonpolyposis Colorectal Cancer (HNPCC / Lynch Syndrome).
IHC staining typically shows brown nuclear staining in positive cells, providing valuable information for both diagnostic and genetic evaluations.

🔬 Features and Benefits MLH1 Antibody

• Key marker for diagnosing colorectal cancer and MSI-related genetic defects
• Produces distinct brown nuclear staining
• Useful for identifying Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
• Compatible with standard IHC staining protocols
• Excellent stability: 18-month shelf life at 2–8 °C

💡 Diagnostic Applications

• Detection of colorectal cancer and evaluation of microsatellite instability (MSI)
• Genetic analysis of MMR-deficient tumors
• Microsatellite instability (MSI) testing in suspected hereditary cancers
• Identification of MMR mutations in Lynch syndrome and related genetic disorders

🌐 Fardad Azma Rad Co.

Fardad Azma Rad Co., the
exclusive representative of Talent Biomedical in Iran, supplies high-quality
immunohistochemistry antibodies, including MLH1.
The company is dedicated to
scientific precision, diagnostic excellence, and international standards,
supporting pathology laboratories and molecular diagnostic centers across Iran.

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