DOG-1 Antibody (Immunohistochemistry)

DOG-1 Antibody (Immunohistochemistry)

The DOG-1 Antibody is one of the most sensitive and specific immunohistochemical markers for diagnosing Gastrointestinal Stromal Tumors (GISTs).
The DOG-1 gene, located on chromosome 11q13, encodes a protein with eight transmembrane domains selectively expressed in GIST cells.
Unlike CD117 (c-Kit), DOG-1 remains positive even in CD117-negative GISTs, making it a superior marker for detecting these tumors.

In IHC staining, DOG-1 exhibits brown membranous and cytoplasmic staining, confirming its diagnostic value in differentiating GIST from other soft tissue and epithelial tumors.

🔬 Features and Benefits DOG-1 Antibody

• Highly specific and sensitive marker for GIST

• Positive even in CD117-negative GISTs

• Clear brown membranous/cytoplasmic staining pattern

• Compatible with FFPE tissues and DAB detection systems

• Excellent stability: 18-month shelf life at 2–8 °C

💡 Diagnostic Applications

• Detection of Gastrointestinal Stromal Tumors (GISTs)

• Differentiation from leiomyoma, schwannoma, and other mesenchymal tumors

• Research on transmembrane proteins and oncogenic pathways

🌐 Fardad Azma Rad Co.

Fardad Azma Rad Co., the exclusive representative of Talent Biomedical in Iran, provides high-quality immunohistochemistry antibodies, including DOG-1.
With a strong focus on scientific precision, diagnostic reliability, and international standards, Fardad Azma Rad supports pathology and molecular diagnostic laboratories throughout Iran.

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