CD117 (c-Kit) Antibody (Immunohistochemistry)

CD117 (c-Kit) Antibody (Immunohistochemistry)

The CD117 (c-Kit) Antibody is an essential immunohistochemical marker used primarily in the diagnosis of Gastrointestinal Stromal Tumors (GISTs) and other c-Kit–expressing neoplasms.
CD117 is the gene product of the c-kit proto-oncogene and functions as a transmembrane tyrosine kinase receptor. It interacts with its ligand, stem cell factor (SCF), and plays vital roles in hematopoiesis, melanogenesis, and gametogenesis.

This marker is expressed on endothelial cells, mast cells, megakaryocytes, hematopoietic stem cells, and melanoblasts.
In IHC staining, CD117 shows distinct brown cytoplasmic and membranous positivity, providing strong diagnostic value for GIST, mast cell disease, and myeloid neoplasms.

🔬 Features and Benefits CD117 (c-Kit) Antibody

• Specific marker for GIST, mast cells, and soft tissue tumors

• Clear membranous and cytoplasmic brown staining pattern

• Useful for differentiating stromal and myeloid neoplasms

• Compatible with FFPE samples and DAB detection systems

• Excellent stability: 18 months at 2–8 °C

💡 Diagnostic Applications

• Detection of Gastrointestinal Stromal Tumor (GIST)

• Identification of Mastocytosis and hematopoietic stem cell neoplasms

• Differentiation of soft tissue and myeloid tumors

• Research on tyrosine kinase signaling and oncogenesis

🌐 Fardad Azma Rad Co.

Fardad Azma Rad Co., the exclusive representative of Talent Biomedical in Iran, provides high-quality immunohistochemistry antibodies, including CD117 (c-Kit).
With a commitment to diagnostic precision, product quality, and international standards, Fardad Azma Rad supports pathology and molecular laboratories throughout Iran.

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