p16 Antibody (Immunohistochemistry)

p16 Antibody (Immunohistochemistry)

The p16 (p16INK4A) Antibody is a key immunohistochemical marker widely used for the detection of HPV-associated neoplasms and other malignancies.
p16 is a cyclin-dependent kinase (CDK) inhibitor that regulates the cell cycle by preventing the G1 to S phase transition through the inhibition of the Cyclin D–CDK4/6 pathway.
This mechanism suppresses abnormal cell proliferation, making p16 a vital tumor suppressor protein.

Overexpression of p16 is commonly observed in cervical carcinomas, as well as head and neck cancers, melanomas, gliomas, lymphomas, and leukemias.
In IHC staining, p16 typically exhibits brown nuclear and cytoplasmic staining in positive cells.

🔬 Features and Benefits

• Sensitive marker for HPV-related tumors

• Distinct brown nuclear and cytoplasmic staining

• Applicable for cancers of the cervix, esophagus, pancreas, lung, and bladder

• Compatible with FFPE tissue and DAB chromogen system

• Excellent stability: 18-month shelf life at 2–8 °C

💡 Diagnostic Applications

• Detection of HPV-associated cervical carcinomas

• Identification of melanoma, glioma, and lymphoid neoplasms

• Evaluation of esophageal, pancreatic, hepatic, and biliary tract carcinomas

• Research on cell cycle regulation and viral oncogenesis

🌐 Fardad Azma Rad Co.

Fardad Azma Rad Co., the exclusive representative of Talent Biomedical in Iran, supplies high-quality immunohistochemistry antibodies, including p16.
With a strong commitment to scientific accuracy, diagnostic reliability, and international standards, Fardad Azma Rad provides comprehensive diagnostic solutions for pathology and molecular laboratories across Iran.

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